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FLUORESCENCE IN SITU HYBRIDIZATION IN IRANIAN PATIENTS WITH PRIMARY BREAST CANCER

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Author(s): P. Mehdipour | M. Atri

Journal: Acta Medica Iranica
ISSN 0044-6025

Volume: 34;
Issue: 3-4;
Start page: 80;
Date: 1996;
Original page

ABSTRACT
Breast cancer is preservative of the genetic heterogeneous alterations. In the present investigation, fluorescence in situ hybridization (FISH) was performed on the fresh primary tumours of 6 patients with infilterating ductal carcinoma. DNA-probe for centromere of chromosome 3 (3cen) was applied and in the total analysis, the majority of interphases presented 1 signal (33.6%) which followed by 3 (28,8%), 2 (16.8%) and 4 (13.5%) signals. Only two tomours showed the +presence of more than 6 signals. The presence of 2 signals could be observed in only one tumour (19.6%). In two tumours, 3 signals (33.1%) was considered as the most frequent alteration and followed by more than 6 signals (25.5% and 18.3% respectively), in tumour ID 27, and 3 signals (43.1%) followed by 1 and 4 signals (30.1% and 17.2% respectively) in tumour ID 33. It is concluded that the FISH-technique is able to clarify and diagnose the numerical alterations of chromosome 3 cen in tumour cells of BC patients.
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