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Forecasting Model of Risk of Cancer in Lung Cancer Pedigree in a Case-control Study

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Author(s): Huan LIN | Wenzhao ZHONG | Xuening YANG | Honghong YAN | Yilong WU

Journal: Chinese Journal of Lung Cancer
ISSN 1009-3419

Volume: 14;
Issue: 7;
Start page: 581;
Date: 2011;
Original page

Keywords: Genetic epidemiology | Familial aggregation | First-degree relative | Lung neoplasms | Inheritance

ABSTRACT
Background and objective Annual lung screening using spiral computed tomography (CT), has a high sensitivity of detecting early lung cancer (LC), but its high rates of false-positive often lead to unnecessary surgery. The aim of this study is to create a forecasting model of high risk individuals to lung cancer. Methods The pathologic diagnoses of LC in Guangdong Lung Cancer Institute were consecutively chosen as the probands. All the members of the first-degree relatives of probands' and their spouses' were enrolled in this study. These pedigrees consisted of 633 probands' pedigrees and 565 spouses' pedigrees. Unless otherwise stated, analyses were performed using the SPSS 17.0 statistical software package. Results Compared with the control, a family history of carcinoma in first-degree relatives was significantly associated with LC risk (OR=1.71, P
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