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FORMULATION OF ACECLOFENAC SUSTAINED RELEASE MATRIX TABLET USING HYDROPHILIC NATURAL GUM

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Author(s): Parasuram Rajam Radhika | Pankaj R. Kharkate | Thangavel Sivakumar

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 2;
Issue: 3;
Start page: 851;
Date: 2011;
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Keywords: Sustained release | Matrix Tablets | Hydrophilic Polymers | Guar Gum | and Tamarind Gum.

ABSTRACT
In order to reduce production costs, a simple, direct compression sustained release formulation consisting of drug Aceclofenac and by using hydrophilic polymer guar gum and tamarind gum as the release modifier was investigated. No interaction between drug and polymer was confirmed by FTIR, which shows the suitability of all excipients with the drug to formulate the sustained release matrix tablets. Five batches of sustained release matrix tablets of Aceclofenac with both guar gum and tamarind gum were prepared by using different drug: polymer ratio i.e. 1; 2, 1:2.5, 1:3, 1:3.5, and 1:4 by direct compression method. The tablets were analyzed for their various parameters such as hardness, friability, weight variation. In- vitro release was performed with the phosphate buffer of pH 7.4 for 24 hrs. Swelling index study was carried out to study the dispersibility of gums at different concentration. The results of in vitro drug release shows that as the concentration of gum increases, swelling index also increases proportionately. Batch F2 and F7 shows maximum drug release with sustained release rate and when compared F7 was more sustained. It is clear through the dissolution study and the kinetic release study of the Aceclofenac matrix tablets prepared using tamarind gum, retarded up to 24 hrs and tamarind gum is best suitable for sustained release formulation by direct compression method.

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