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Formulation and characterization of ritonavir loaded polymethacrylate microspheres for oral delivery

Author(s): J. Josephine Leno Jenita*, Madhusudhan N T, B.Wilson, T.Vithya and K.B.Premakumari

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 7;
Start page: 2159;
Date: 2011;
Original page

Keywords: Microspheres | Eudragit S 100 | Ritonavir | in vitro release | Release Kinetics.

One of the most effective approaches for achieving novel drug delivery dosage forms such as sustained release, controlled release is microencapsulation. Ritonavir was microencapsulated with Eudragit (S 100), using a solvent evaporation method. Ritonavir loaded microspheres were subjected to micromeritic properties including angle of repose and particle size determination. Microspheres were also subjected to drug loading, in vitro drug release as well as for scanning electron microscopy. The prepared microspheres were white, free-flowing, and almost spherical in shape. The drug-loaded microspheres show 98-112% drug entrapment, angle of repose was in the range of 27.010 -34.210, and particle size was in the range of 35-45μm. In vitro drug release studies were carried out up to 10 h in two different pH media, i.e., acidic buffer (pH 1.2) and SLS solution (0.7%). The drug-polymer concentration of dispersed phase influences the particle size and drug release properties. The rate of drug release followed zero order kinetics.
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