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FORMULATION DEVELOPMENT AND EVALUATION OF IMMEDIATE RELEASE BILAYER TABLETS OF TELMISERTAN AND HYDROCHLOROTHIAZIDE

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Author(s): Bhavsar Bhavesh | Chauhan Manish | Biswal Biswajit

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 4;
Issue: 9;
Start page: 117;
Date: 2013;
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Keywords: Immediate release tablet | immediate release bilayer tablet | Telmisartan | HCTZ | Dissolution in 7.5 pH buffer.

ABSTRACT
A low-dose combination of two different agents reduces the dose related risk; the addition of one agent may counter act some deleterious effects of the other. Using low dosage of two different agents minimizes the clinical and metabolic effects that occur with maximal dosage of individual component of the combined tablet and thus dosage of the single component can be reduced. The primary objective of formulation development was to develop a stable, essentially similar, robust and bioequivalent formulation of Telmisartan and HCTZ combination for synergistic effect which complies with the Reference product.
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