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FORMULATION DEVELOPMENT AND EVALUATION OF MOUTH DISSOLVING TABLET OF BAMBUTEROL HYDROCHLORIDE

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Author(s): Jain Hardik | Arora Vimal | Sharma Vishvanath | Jaithlia Rajiv

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 2;
Issue: 7;
Start page: 109;
Date: 2011;
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Keywords: Bambuterol hydrochloride | direct compression | superdisintegrants.

ABSTRACT
The aim of the present study was to prepare mouth dissolving tablets of Bambuterol hydrochloride by using pertinent disintegrants. The tablets were prepared using mannitol and lactose along with two levels of disintegrant by direct compression method. The superdisintegrants used in this study were croscamellose sodium (CCS) and sodium starch glycolate (SSG). The tablets were evaluated for uniformity of weight, thickness, hardness, friability, wetting time, water absorption ratio, disintegration time and dissolution study. Using the same excipients, the tablets were prepared, without disintegrants and were evaluated in the similar way. Fromm the result obtained, it can be concluded that the tablet formulation (batch B4) showed disintegration time of 25±2.0 seconds in vitro. The hardness, friability and dissolution rate of prepared tablet (batch B4) were found to be acceptable according to standard limits.

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Tangokurs Rapperswil-Jona

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