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FORMULATION DEVELOPMENT AND EVALUATION OF SOLID LIPID NANOPARTICLES OF ACECLOFENAC USING SOLVENT INJECTION METHOD.

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Author(s): ManMohan Kaushik | Govind Mohan | Tarkeshwar Prasad Shukla | Niranjan Upadhyay | Abhishek Mathur | Bismi P. Cherian

Journal: Journal of Drug Delivery and Therapeutics
ISSN 2250-1177

Volume: 2;
Issue: 4;
Date: 2012;
Original page

ABSTRACT
Solid lipid nanoparticles (SLN) of aceclofenac were prepared by solvent injection method. Glyceryl behenate (Compritol 888 ATO) was used as lipid core, and Poloxamer 188 as the surfactant. Isopropyl alcohol (IPA) was used to dissolve both lipid and drug. The mean particle size measured by laser diffraction (LD) was 226.9 nm and the surface morphology was determined by scanning electron microscopy. The entrapment efficiency (EE) was found to be 90%. In-vitro dissolution was found to be 90.22%.
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