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Formulation development and evaluation of Venlafaxine hydrochloride sustained release pellets

Author(s): Akelesh T*, Rakesh S, Ramya R, Venkatnarayanan R

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 10;
Start page: 3287;
Date: 2011;
Original page

Keywords: Venlafaxine HCl | Pellets | Sustained release capsules | Drug release study

The objective of the present study is to develop a pharmaceutically equivalent, stable, cost effective and quality improved formulation of Venlafaxine HCl pelletsit in the form of sustained release capsule and compare with that of the marketed dosage form. The experimental work is divided into pre formulation studies,formulation development and evaluation of sustained release pellets. In the present work the preparation of pellets containing different polymers has beeninvestigated with the intention of gaining a deeper understanding of some of the formulations factor that influences the properties of the same. Pellets wereevaluated for bulk density, friability and angle of repose. Sustained release capsules were evaluated for drug content analysis and in vitro dissolution. Among thedifferent formulations prepared, formulation no.10 coated with ethyl cellulose N-50 4.5%, Hydroxy propyl methyl cellulose 15%, Steric acid 5%, was found besatisfactory. Sustained Release capsule from formulation no10 gave satisfactory dissolution profile.

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