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FORMULATION AND EVALUATION OF ASYMMETRIC MEMBRANE CAPSULE OSMOTIC PUMP OF GLICLAZIDE

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Author(s): Teraiya Sandip R | Jadav Mukesh M | Bhavana A. Patel | Kunal N. Patel | Poras A. Patel

Journal: International Journal For Pharmaceutical Research Scholars
ISSN 2277-7873

Volume: 1;
Issue: 2;
Start page: 155;
Date: 2012;
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Keywords: Asymmetric membrane capsule | Osmotic pump | Antidiabetic agent | Gliclazide | Cellulose acetate | Ethyl cellulose

ABSTRACT
The aim of this study was to demonstrate that the asymmetric membrane capsule can be used to deliver apoorly water soluble drug with a pH sensitive solubility such as gliclazide. In order to obtain the desireddelivery duration, the drug was solubilized with the use of a pH-controlling excipient. The capsule wallmembrane was made by a phase inversion process, in which asymmetric membrane was formed on glassmold pins by dipping the mold pins into a coating solution containing a polymeric material followed bydipping into a quench solution. This study evaluates the influence of coating formulation that wascellulose acetate (CA), ethyl cellulose (EC), and plasticizer (glycerin and PEG 600). Results showcapsule that made by CA with glycerol and PEG 600(F8), which appear in asymmetric structure and areable to release gliclazide(GLZ) in significant percentage. Results show that sodium bicarbonate and Dmannitolis able to promote the release of GLZ from polymeric capsules prepared with CA withasymmetrical membrane. The addition of solubilizer, sodium lauryl sulphate (SLS) could enhance therelease of GLZ by micelle formation of GLZ. Based on these results, influence of core formulationvariables, including D-mannitol, sodium bicarbonate and the added amount of SLS were examined onthe release of GLZ. It was found that HPMC 15cp was suitable to be a thickening agent and both addedamount of HPMC and SLS showed a comparable and profoundly positive effect. In vitro release studiesfor all the prepared formulations were done (n=3). Statistical test (Dunnett’s multiple comparison test)was applied for in vitro drug release at P>0.05. The best formulation closely corresponded to themarketed formulation by a similarity (f2) value of 78.36 and difference (f1) value of 4.49. The drugrelease was independent of pH but dependent on the osmotic pressure of the dissolution medium. Therelease kinetics followed the First order model and the mechanism of release was anomalous type.
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