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FORMULATION AND EVALUATION OF BILAYER TABLETS OF TWO INCOMPATIBLE DRUGS AMLODIPINE BESILATE AND LOSARTAN POTASSIUM

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Author(s): Rama | Mitesh. R. Bhoot

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 4;
Issue: 9;
Start page: 136;
Date: 2013;
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Keywords: Bi layer tablets | Amlodipine besilate | Losartan potassium | crospovidone | Sodium starch glycolate | in vitro drug release.

ABSTRACT
The main goal of this study was to develop a stable formulation for two incompatible anti hypertensive drugs Amlodipine besilate and Losartan potassium as an immediate release bi layer tablet and to evaluate its dissolution studies. The formulation development work was initiated with wet granulation for losartan potassium layer and direct compression for amlodipine besilate layer. Super disintegrants like Crospovidone, Sodium starch glycolate (SSG) were used in all the formulations and its role on disintegration and dissolution properties of the drug were studied. The prepared tablets were evaluated for weight variation, wetting time, hardness, thickness, friability, % drug content, disintegration time, in vitro drug release. Formulation F8 showed a highest drug release of 84.02 % for amlodipine besilate and 90.08 % for losartan potassium in 30 minutes which was selected as optimized formulation and considered for further studies. The stability studies, shown that the formulation F8 was stable enough at 40◦C / 75 % RH for a period of 6 months. The results suggest the feasibility of developing bi layer tablets consisting of amlodipine besilate and losartan potassium for the convenience of patients with hypertension.
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