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FORMULATION AND EVALUATION OF DILTIAZEM HYDROCHLORIDE PRESS-COATED TABLET

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Author(s): Kapse Pankaj

Journal: International Journal of Pharmaceutical Research and Development
ISSN 0974-9446

Volume: 3;
Issue: 2;
Start page: 26;
Date: 2011;
Original page

Keywords: Press-coated tablet | time lag | HPMC | weight ratio | sustained release

ABSTRACT
An oral press-coated tablet was developed by means of direct compression to achieve the time-controlled disintegrating or rupturing function with a distinct predetermined lag time and produce sustained drug delivery. This press-coated tablet containing Diltiazem hydrochloride (DIL) as a model drug in the inner core was formulated with an outer shell by different weight ratios of low viscosity grade hydrophilic polymer of Hydroxypropylmethylcellulose (HPMC) 3-cps, 5-cps, 6-cps powder respectively and weight ratio of that used 1:2.86, 1:3, 1:4, 1:5 for each press-coated polymer to core tablet. The release profile of the press-coated tablet exhibited a time period without drug release (time lag) in pH 1.2 followed by a rapid and complete release phase, the lag phase was markedly dependent on the weight ratios of Core. This ratio of core to press coated polymer press coated tablets displayed acid resistance in the stomach. In vitro dissolution test in pH 6.8 the release of press-coated tablet shows sustained drug release and to avoid gastrointestinal disturbances.1:3 weight ratio shows better sustained release action then other.
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