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Formulation and Evaluation of Extended Release Tablet of Divalproex sodium

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Author(s): Lakhani Khushbu M. | Shah Shweta V. | Patel Kunal N. | Patel Bhavana A. | Patel Poras A.

Journal: International Journal For Pharmaceutical Research Scholars
ISSN 2277-7873

Volume: 1;
Issue: 2;
Start page: 122;
Date: 2012;
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Keywords: Extended release tablet | Divalproex sodium | HPMC K100M | Eudragit L100

ABSTRACT
In the present work, an attempt was made to design an oral Extended release matrix tablet of Divalproexsodium and to optimize the drug release profile using 32 full factorial design. Tablets were prepared bydirect compression method using HPMC K100M and Eudragit L100 as matrix forming polymers.Tablets were evaluated for various physicochemical parameters like Hardness, Thickness, Friability,Weight variation test, Content Uniformity and In vitro drug release. All the formulations complied withpharmacopoeial standards. A 32 full factorial design for 2 factors at 3 levels each was employed tosystematically optimize drug release profile. HPMC K100M and Eudragit L100 were taken as theindependent variables. The dependent variables selected were % of drug released in 3 hrs, % of drugreleased in 12 hrs. In vitro drug release study showed that batch F8 (HPMC K100M-15%, EudragitL100-10%) was found to be optimized as it had almost identical dissolution profile with marketedproduct. The formulated tablets exhibited Non–fickian drug release kinetics approaching Zero–order asthe value of release rate exponent (n) varied between 0.6024 and 0.7354, resulting in regulated andcomplete release until 24 hrs. The polymer HPMC K100M and Eudragit L100 had significant effect onthe drug release from the tablets (P
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