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Formulation and Evaluation of Fast Dissolving Film of Levocetirizine Dihydrochloride Using Different Grades of Methocel

Author(s): Dhagla Ram Choudhary*1, Vishnu A Patel2, Usmangani K Chhalotiya1, Harsha V Patel1, Aliasgar J Kundawala1

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 9;
Start page: 2919;
Date: 2011;
Original page

Keywords: Levocetirizine dihydrochloride | fast dissolving film | hydroxyl propyl ß – cyclodextrin | methocel | solvent evaporation technique.

Levocetirizine dihydrochloride is a non-sedative antihistaminic, and drug of choice in many anti-allergic conditions. This work aimed to develop fast dissolvingfilms of levocetirizine for the treatment of acute allergic rhinitis and chronic urticaria to produce faster on set of action. Fast dissolving films were prepared bysolvent casting method using different grades of methocel K3, E3, E5, and E15 as film former and PG, PEG 400 and tween 80 as plasticizer. Bitterness oflevocetirizine was masked by forming inclusion complex with HPBCD. The complex was evaluated by XRD, DSC and FT-IR. Optimized films were evaluated formechanical properties, drug content and dissolution characteristics. The combination of methocel E15 and PEG 400 exhibited excellent mechanical properties(Tensile strength 6.32 N/mm2), drug content (98.35 %) and dissolution characteristic (DT 47 sec). The research work done here suggested the exciting possibilityof levocetirizine as fast dissolving film.
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