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FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF ACETAMINOPHEN

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Author(s): Abhay Kumar Mourya et al.

Journal: International Journal of Pharmaceutical Sciences and Research
ISSN 0975-8232

Volume: 3;
Issue: 2;
Start page: 610;
Date: 2012;
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Keywords: Optimized formulation | Poor compression properties | Combination ratios | Superdisintegrant | Compressibility characteristics

ABSTRACT
The present research work has been carried out for an optimized formulation of co-processed directly compressible vehicles in the preparation of the Acetaminophen mouth fast dissolving tablets (MFDTs). Acetaminophen was chosen due to its poor compression properties. Di-calcium Phosphate(DCP) was incorporated in the neutralized aqueous starch dispersion to prepare co-processed excipient. Co-processed direct compressible DCP and Starch used as co-processed excipient were taken in good formulation ratio such as (25:75) and Cross Povidone used as superdisintegrant. The effects of other superdisintegrants were studied in the best formulation F5. Formulation F5 was found to be optimum compressibility characteristics hardness 3.62±0.40 to 4.68±0.31 kg/cm2 with fast disintegration (10 sec) compare to other formulations.

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