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FORMULATION AND EVALUATION OF FLOATING DRUG DELIVERY SYSTEM OF AMOXYCILLIN TRIHYDRATE

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Author(s): Marella Radhakrishna | K.G.Parthiban | Nelluri Ramarao | Nagapuri Santhoshi Deepika | Perumulla Abhishek

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 3;
Issue: 8;
Start page: 233;
Date: 2012;
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Keywords: Amoxycillin trihydrate | xanthan gum | Helicobacter pylori | Ethocel | HPMC K4M.

ABSTRACT
The present study was designed to formulate and evaluate balanced Floating Drug Delivery Systems as controlled release modules, which prolongs the release rate of the drugs. Amoxycillin is an anti- bacterial acts by inhibiting the synthesis of bacterial cell walls. It inhibits cross-linkage between the linear peptidoglycan polymer chains that make up a major component of the cell walls of both Gram-positive and Gram-negative bacteria. Helicobacter pylori exists in the gastric mucous layer or epithelial cell surfaces. Thus, the concentration and resident time of Amoxycillin trihydrate in stomach would be effective for complete eradication of Helicobacter pylori. Formulation of Amoxycillin trihydrate as gastro retentive drug delivery systems (GRDDS) is especially advantageous over other prolonged type drug delivery systems and conventional tablets because the drug is having absorption window in upper part of gastro intestinal tract and having relatively short half life. Amoxycillin trihydrate was taken as the model drug to optimized formulations was prepared. The single unit floating matrix tablets of Amoxycillin trihydrate with different natural and synthetic polymers such has HPMC K4M, HPMC K15M, HPMC K100M by taking single polymer in the formulation.The evaluation of physicochemical characteristics of all formulations and to carryout in vitro drug release studies using USP XXIV apparatus and data were analyzed at 272nm.The drug release of Amoxycillin trihydrate from formulations containing HPMC K4M,HPMC K15M followed zero order kinetics where has formulation containing combination of xanthan gum(natural polymer) and HPMC K100M(synthetic polymer) followed Higuchi and First-order pattern respectively. Of all the formulations in which combination of polymers has retarded the drug successfully upto 12 hours.
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