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FORMULATION AND EVALUATION OF LORNOXICAM FAST DISSOLVING TABLET

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Author(s): Parikh Bhavik Anjankumar | M. Najmuddin | Kulkarni Upendra | Hariprasanna R.C

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 2;
Issue: 4;
Start page: 130;
Date: 2011;
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Keywords: Lornoxicam | Crosspovidone | camphor | Menthol | Sodium Bicarbonate | Citric acid

ABSTRACT
The goal of the present investigation was to design and evaluated taste mask oral disintegration tablet of lornoxicam, which is NSAID by sublimation & effervescent method using various excipients (menthol, camphor, citric acid and sodium bicarbonate) in different concentrations. In sublimation method drug:-cyclodextrine complex was prepared by kneading method. Crosspovidone (5%) was used as superdisintegrants. The prepared formulations were evaluated for hardness, friability, and disintegration time, wetting time, drug content and in-vitro drug release studies. Fast dissolving tablet prepared by sublimation method with 10% menthol and effervescent method with 15 % sodium bicarbonate and 5% citric acid showed 98.95% in 6 minute and 98.36 % of drug release respectively.
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