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Formulation and Evaluation of Microparticles for Controlled Delivery of Tramadol HCl

Author(s): Patel SB | Patel VR | Patel KN | Patel BA | Patel PA

Journal: International Journal For Pharmaceutical Research Scholars
ISSN 2277-7873

Volume: 1;
Issue: 2;
Start page: 136;
Date: 2012;
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Keywords: Tramadol HCl | Microparticles | Eudragit RS100 and RL100 | Scanning Electron Microscopy

Although Tramadol has less analgesic power than morphine, it presents fewer side effects andconsequently is currently considered as a drug of choice in the treatment of chronic pain. The aim of thepresent work was to study preparation of controlled drug delivery of Tramadol HCl via oral route. Drugwas encapsulated within polymethacrylate copolymer i.e. Eudragit RS100 and Eudragit RL100, bysolvent evaporation method using acetone/liquid paraffin system. FTIR and DSC of Tramadol HCl andit combination with Excipients shows no change in peak of absorbance and melting point.Microparticles of different drug-polymer concentrations 1:1, 1:2, 1:3 and 1:4 were prepared. Magnesiumstearate was used as droplet stabilizer and lubricant in concentration of 0.3% (v/v). Selectedformulations were characterized for their micromeritics property, % yield, drug loading, particle size,surface morphology and release behaviour. In-vitro dissolution tests were performed by usingdissolution media with two different pH i.e. 1.2 pH for 2 hrs and 6.8 pH for 10 hrs. All the selectedformulations exhibited a controlled release for almost 12 hrs. Among the entire prepared batches F25shows good % drug loading (48.33%), high % yield (93%) and good controlled release (98%) within 12hrs. The mean particle size of microspheres ranged from 252 ± 24.54 μm. Scanning electron microscopyof microspheres revealed a spherical and uniform appearance with smooth surface. Stability study wasperformed for batch F10 shows 96.78% drug release in 12 hrs. Release of TmH was best fitted toHiguchi model and Korsmeyer-Peppas model because it presented highest values of correlationcoefficient (R2 = 0.9822).
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