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FORMULATION AND EVALUATION OF MOUTH DISINTEGRATING TABLETS OF FAMOTIDINE BY USING HIBISCUS ROSA - SINENSIS MUCILAGE AND TREATED AGAR

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Author(s): Halakatti Prabhu K. | Omer Shaista | Gulgannavar Rajanna S. | Patwari Pranesh K.

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 1;
Issue: 2;
Start page: 497;
Date: 2010;
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Keywords: Mouth disintegrating tablets | Water absorption ratio | Treated agar | Famotidine.

ABSTRACT
Mouth disintegrating tablets are those tablets which disintegrate/dissolve in the mouth with in the fraction of seconds. These tablets are helpful for all age groups especially geriatric and paediatric patients. This type of dosage forms helps a lot to dissolve in the mouth without the need of water and also increase the bioavailability of the drugs rapidly. Newer methods are also applied in preparing the MDT’s.Purpose of the present work is to formulate the mouth dissolving tablets of Famotidine by using natural polymers to achieve quick onset of action, to increase absorption and helps to obtain maximum bioavailability. Famotidine dissolving tablets were prepared with mucilage of Hibiscus Rosa - sinensis Linn and treated agar. Pre-compression parameters like angle of repose and post-compression parameters like wetting time, water absorption ratio, in-vitro disintegration and in-vitro dispersion time were studied. The hardness, friability and drug content of all the formulations were found to be within the limits. The best formulations FHR4 and FTG3 have shown good disintegration time, hardness and friability. The best promising formulations were also found to be stable. This natural polymers helps a lot in economic way to achieve rapid disintegration and rapid onset of drug action in the body.

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