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FORMULATION AND EVALUATION OF MOUTH DISSOLVE TABLETS OF CEFIXIME

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Author(s): Sharma Vijay | Singh Lalit | Saxena Pratiush | Kumar J. Ashok

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 2;
Issue: 5;
Start page: 171;
Date: 2011;
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Keywords: Mouth dissolving tablets | Cefixime trihydrate | Super Fast Tablet Disintegrators.

ABSTRACT
Aim of this research work was to develop mouth dissolve tablet that disintegrates rapidly in mouth and formulate tasteless complex of drug Cefixime. Cefixime is an oral third generation cephalosporin antibiotic. It is used to treat gonorrhea, tonsillitis, and pharyngitis. The tablets were prepared using different concentration of disintegrant by direct compression method.The superdisintegrants used in this study were Sodium starch glycolate (SSG), cropovidone (CP), Cross‐carmillose sodium (CCS) and Kyron T 314. The formulated tablets were evaluated for uniformity of weight, thickness, hardness, friability, wetting time, water absorption ratio, disintegration time (DT) and dissolution study. The conventional tablets of Cefixime were prepared by using the same excipients ,without addition of Super fast tablet disintegrators and were evaluated in the similar way. From the results obtained, it can be concluded that the tablet formulation (batch FDT5) showed Disintegration time of 30±2.4 seconds in vitro. Also the hardness, friability and dissolution rate of prepared tablets (batch FDT5) were found to be acceptable according to standard limits.

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