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FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET OF AMLODIPINE BESYLATE

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Author(s): S. Suresh | A. Senthil | C. Manikandan | Ravikumar | Narayana Swamy VB.

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 2;
Issue: 9;
Start page: 161;
Date: 2011;
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Keywords: Amlodipine besylate | Mouth dissolving tablets | Superdisintegrants | Direct compression.

ABSTRACT
Mouth dissolving tablets is the fast growing and highly accepted drug delivery system, convenience of self administration, compactness and easy manufacturing. Amlodipine besylate is a drug that is used for treating high blood pressure, certain types of angina, and coronary heart failure. Hence the objective of the work is to develop mouth dissolving tablets of amlodipine besylate by direct compression method using three super disintegrants, viz., hypromellose, crospovidone and sodium starch glycolate at different concentrations with microcrystalline cellulose. The blend was examined for angle of repose, bulk density, tapped density, compressibility index and hausner’s ratio. The prepared tablets were evaluated for thickness, hardness, friability, and weight variation, content uniformity, wetting time, water absorption ratio, in vitro dispersion time, dissolution studies and FTIR studies. Twelve formulations F1 to F12 were prepared with three super disintegrants with different concentration. The optimum formulation was chosen and their optimum results were found to be in close agreement with experimental finding. Among three super disintegrants crospovidone F7 emerged as overall best formulation. Short term stability studies on the formulations indicated no significant changes in the drug content and in vitro dispersion time.
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