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FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF ATENOLOL BY DIRECT COMPRESSION METHOD

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Author(s): Lakshmi C.S.R.*, Akul Sagar, Totala Anup, Choudhary Jitesh, Patel Nitesh

Journal: International Journal of Drug Formulation and Research
ISSN 2229-5054

Volume: 2;
Issue: 3;
Start page: 356;
Date: 2011;
Original page

Keywords: Mouth dissolving tablets | atenolol | crospovidone | sodium starch glycolate | croscarmellose sodium.

ABSTRACT
Atenolol is a β1 selective antagonist without membrane stabilizing or intrinsic sympathomimetic activities.Administration of conventional tablets of atenolol has been reported to exhibit fluctuation in the plasma druglevels, resulting either in manifestation of side effects or reduction in drug concentration at the receptor site. Inthe present study an attempt has been made to prepare mouth dissolving tablets (MDT) of atenolol in the oralcavity with enhanced dissolution rate. The mouth dissolving tablets of atenolol were prepared using variousconcentrations of super disintegrating agents like croscarmellose sodium, crospovidone, sodium starch glycolateand L-HPC by direct compression method. The blend was examined for angle of repose, bulk density, tappeddensity, total porosity, compressibility index and Hausner’s ratio. The prepared tablets were evaluated for weightvariation, hardness, drug content, friability, Thickness, Diameter, disintegration time, Wetting time anddissolution rate. An effective pleasant testing formulation released 98.93% drug within 1 minute. It wasconcluded that superdisintegrant addition technique is a useful method for preparing mouth dissolving tablets bydirect compression method.
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