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FORMULATION, EVALUATION AND OPTIMIZATION OF OSMOTIC DRUG DELIVERY SYSTEM FOR A HIGHLY INSOLUBLE DRUG

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Author(s): Sharma anurag R | Shaikh rizavana G | Kunal N. Patel | Bhavana A. Patel | Poras A. Patel

Journal: International Journal For Pharmaceutical Research Scholars
ISSN 2277-7873

Volume: 1;
Issue: 2;
Start page: 296;
Date: 2012;
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Keywords: Push Pull Osmotic Drug Delivery System | Highly insoluble drug Osmotic pump | Antipsychotic agent | PEO and Cellulose acetate

ABSTRACT
The present study focuses on the preparation of push pull osmotic drug delivery system for a highlyinsoluble drug, an antipsychotic category. The main aim is to improve the site specification and toprovide the controlled release of drug for once-a-day drug delivery system with zero order drug releaseprofile with applying drug release kinetic modelling. The push pull osmotic tablets were prepared by wetgranulation method; the drug layer consists of the drug, osmotic agent, suspension agent and in pushlayer extender, osmotic agent and pigment to distinguish push layer form drug layer. The coating wascarried out by cellulose acetate (CA) and plasticizer was used as propylene glycol. This study evaluatesthat regardless of the drug properties which do not significantly affect the drug delivery, the releasekinetics is mainly controlled by some factors as, the plasticizer proportion in the membrane, the osmoticagent proportion and the drug layer polymer grade. The influence of each factor was investigateddefining their acceptability range. Results shows that tablet made by PEO200K and diluents used in druglayer and PEO7000K and sodium chloride in push layer with 10% of CA coating, the plasticizer contentwas upto 20% to 30% and 0.8mm of orifice diameter. Results, shows that the use of suspension agent indrug layer affects the drug release. The formulation batch F13 was taken as ideal optimized batch and itfollows the zero order drug release. On the basis of results the effect of orifice diameter, polymerconcentration in drug layer, coating composition and plasticizer amount was tested and promising resultswere found. The drug release was independent of pH but dependent on the osmotic pressure of thedissolution medium. The release kinetics followed the Zero order model.
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