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FORMULATION AND EVALUATION OF ORO DISPERSIBLE TABLETS OF METOPROLOL TARTRATE BY DIRECT COMPRESSION USING SUPER DISINTEGRANTS

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Author(s): A.Senthil | T.Sivakumar | V.B.Narayanaswamy | Prajapathi Ashish S | Patel Viral G

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 2;
Issue: 1;
Start page: 224;
Date: 2011;
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Keywords: Oro dispersible tablets | Super disintegrants | Metoprolol tartrate | direct compression.

ABSTRACT
The objective of the present investigation was to prepare orodispersible tablets of metoprolol tartrate by direct compression method using three super disintegrants, cross carmellose sodium, cross povidone and sodium starch glycolate at different concentrations. Oro dispersible tablet is the fast growing and highly accepted drug delivery system, convenience of self administration, compactness and easy manufacturing. Metoprolol tartrate is a antihypertensive agent, half life is 3 hrs and bioavailability is 40%. It is completely absorb after oral administration. Microcrystalline cellulose is used as diluent. The bland was examined for angle of repose, bulk density, tapped density, compressibility index and Hausner’s ratio. The tablets were evaluated for thickness, hardness, friability, and weight variation, content uniformity, wetting time, Water absorption ratio, In-vitro dispersion time, dissolution studies and FTIR studies. Twelve formulations F1 to F12 were prepared with three super disintegrants with different concentration. The optimum formulation was chosen and their optimum results were found to be in close agreement with experimental finding.

Tango Jona
Tangokurs Rapperswil-Jona

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