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Formulation and evaluation of press -coated indomethacin tablets for pulsatile drug delivery system

Author(s): Abhijit Moon*, Manish Kondawar, Rohit Shah

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 3;
Start page: 564;
Date: 2011;
Original page

Keywords: Press-coated tablet | lag time | ethylcellulose | hydroxy propyl methyl cellulose | pulsatile drug delivery system.

An oral press-coated tablet was developed by means of direct compression and wet granulation to achieve the time-controlled tablet with a distinct predetermined lag time. This press-coated tablet containing Indomethacin in the inner core was formulated with an outer shell by different weight ratios of hydrophobic polymer of ethylcellulose powder and hydrophilic polymer hydroxy propyl methyl cellulose. The effect of the formulation of an outer shell comprising both hydrophobic polymer and hydrophilic polymer on the time lag of drug release was investigated. The typical pulsatile profile was shown by tablets prepared by direct compression and wet granulation method. The release profile of the press-coated tablet exhibited a time period without drug release (time lag) followed by a rapid and complete release phase. In vitro drug release study shows that as hydrophilic polymer increases lag time decrease. Press coated tablets coated by dry mixing and by wet granulation showed variations in lag time. As compared to dry mixed blend method wet granulation method gives less lag time.
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