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FORMULATION AND EVALUATION OF TASTE MASKED ORALLY DISINTEGRATING TABLETS OF SITAGLIPTIN PHOSPHATE MONOHYDRATE

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Author(s): Abbaraju Prasanna Lakshmi | Ajay kumar.B | Vishal.K

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 3;
Issue: 9;
Start page: 305;
Date: 2012;
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Keywords: Taste masking | Sitagliptin Phosphate Monohydrate | Mannitol | Super disintegrants | rapid disintegrating tablets.

ABSTRACT
The purpose of the work is to mask the unpleasant taste of sitagliptin phosphate monohydrate with mannitol by co-grinding method and to formulate it as an oral disintegrating tablet by direct compression method. Drug-mannitol complexes were taken in 1:1, 1:1.5 and 1:2 ratios and tested for in vitro and in vivo bitter masking capacity of mannitol, drug content and molecular property. Different super-disintegrants like croscaramellose, sodium starch glycolate and crospovidone was used as disintegrating agents. The prepared tablets were characterized for tensile strength, wetting time, water absorption ratio, and In vitro and in vivo disintegration time. In addition, aspartame is used as sweetening agent which gives more pleasant taste in the mouth. Among all the formulations F1 to F6, Formulation F6 has good taste masking capacity and fast disintegration within 40sec. Furthermore, 96.7% of the drug has been released in 15min.The results disclosed that the productivity of taste masking of the drug has been done effectively with mannitol and 40mg of crosscarmellose sodium is efficient for rapid disintegrating of tablet.
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