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Formulation and Evaluation of Topical Hydrogel Patch Containing Amide Type Local Anaesthetic Agent

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Author(s): Jayrajsinh Sarvaiya | Chintan Tank | Kosanam Divakar | Jay Upadhyay | G.K.Kapse

Journal: International Journal For Pharmaceutical Research Scholars
ISSN 2277-7873

Volume: 1;
Issue: 3;
Start page: 164;
Date: 2012;
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Keywords: Hydrogel | Topical patch | Lidocaine | Sodium polyacrylate | Brij 30 | Transcutol

ABSTRACT
Hydrogel based drug delivery systems provides significant effect in designing sustained release topical dosage forms. Topical patch containing drug in hydrogel type polymer matrix provides not only targeted drug flux through the skin but also provides cooling effect on application site. Topical hydrogel patch containing lidocaine was prepared by using sodium poly acrylate as bioadhesive polymer. Effect of brij 30 and transcutol was also evaluated on topical flux of lidocaine base from hydrogel patch. Transcutol (10% w/w) provides sufficient drug release in contrast to brij 30(4%w/w) in prepared hydrogel patches. Maintenance of uniformity of weight is one of the critical task in preparation of hydrogel patch as polymers used are highly water absorbent. Excess amount of penetration enhancers leads to alter adhesive property of bioadhesive patch so formulation was optimized with Sodium polyacrylate (7%w/w) as the desired concentration for necessary bioadhesiveness and zinc oxide as cross linking agent.
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