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FORMULATION AND EVALUATION OF VENLAFAXINE HCl MICROSPHERES

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Author(s): Bindu Madhavi B | Zulkar Nain Kamal MD | Kusum B | Srikanth V | Ramalingam.R | Ramalingam.R

Journal: Hygeia : Journal for Drugs and Medicines
ISSN 0975-6221

Volume: 3;
Issue: 1;
Start page: 64;
Date: 2011;
Original page

Keywords: Venlafaxine HCl | anti depressantactivity | ethyl cellulose microspheres | sustain release dosage forms.

ABSTRACT
Venlafaxine HCl is the freely water solubledrug with antidepressant activity. It is available in a dose of 25mg-45mg.Being highly soluble drug there is possibility of burst effect which causessudden peak levels of drug in blood. It is having many side effects and with ahalf life around 5 hours. To reduce the adverse effects due to burst effect andto have the sustain action of the drug we have prepared the ethyl cellulosemicrospheres of the drug. The microspheres were prepared by the emulsification andsolvent evaporation method. The prepared microspheres were evaluated mainly forthe sustain release of the drug and then the anti depressant activity in albinomice apart from the other tests like % drug encapsulation, particle size anddrug polymer compatibility by the FTIR studies. The method had resulted in goodencapsulation efficiency and micron sized ethyl cellulose spheres. The drugrelease was found to be sustained for 16 hours and was found to follow thePeppas kinetics
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