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FORMULATION, OPTIMIZATION AND EVALUATION OF STOMACH SPECIFIC IN-SITU GEL OF HYDROCHLOROTHIAZIDE

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Author(s): Bala Saroj | Mahatma O.P | Azim Md. Sabir

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 4;
Issue: 9;
Start page: 77;
Date: 2013;
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Keywords: Hydrochlorothiazide | In-situ | polymer | Pectin | viscosity

ABSTRACT
The objectives of this research work were preparation, optimization and evaluation of in situ gelling system of Hydrochlorothiazide based on pectin that retains in the stomach by adherence to gastric wall providing an increased gastric residence time resulting in prolonged drug delivery in gastrointestinal tract. Pectin was used as a polymer and CaCO3 as a cross-linking agent. The in situ formulation exhibited the expectations, viscosity, drug content and sustained drug release. This study reports that oral administration of aqueous solutions containing pectin results in formation of in situ gel and such formulations are homogenous liquids when administered orally and become gel at the contact site. The results of a 32 full factorial design revealed that the concentrations of pectin and CaCO3 significantly affected the dependent variables of viscosity, drug content (%) and Q18. These in situ gels are, thus, suitable for oral sustained release of Hydrochlorothiazide.
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