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Formulation and in vitro evaluation of floating drug delivery system for salbutamol sulphate

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Author(s): I. Sarath Chandiran | B. Pavan Kumar | V. Narayan

Journal: International Journal of Pharmacy and Biomedical Sciences
ISSN 0976-5263

Volume: 01;
Issue: 01;
Start page: 12;
Date: 2010;
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Keywords: Salbutamol sulphate | Floating matrix tablets | Methylcellulose | HPMC K100M | HPMC K4M

ABSTRACT
The purpose of this research work is to formulate the salbutamol sulphate as a floating matrix tablets and control the drug release up to 24 h for administration as once daily dose. Salbutamol Sulphate is a short acting bronchodilators which have short biological half life about 2 - 4 h. Floating matrix tablets were formulated by using swelling polymer like Methylcellulose, Hydroxy propyl methyl cellulose (K100M, K4M) with different concentration 25, 50, 75 % w/w of the polymer were used for the preparation of the floating matrix tablets. The formulation variables like hardness, polymer concentrations, and shape of the tablets were optimized to achieve the floating nature of the tablet in stomach for 24 h. In addition stearic acid is included in this formulation to evaluate their release characteristics. From this the hydrophilic floating matrix control the release up to 12 h with HPMC K100M at 75 % w/w of the polymer concentration. The formulations, which have stearic acid retards the drug release by controlling the water penetrations in to the floating matrix tablets, sustained their drug release above 12 h. The floating matrix tablets with minimum hardness of 5 kg/cm2 and round shaped tablets exhibited better buoyancy.

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