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FORMULATION AND IN VITRO EVALUATION OF OMEPRAZOLE FAST DISSOLVING TABLETS

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Author(s): Soumya Missula | Yarlagadda Ankamma Chowdary | Gayathri Pedamallu | Kondempudi Sai Krishna Mohan | Mellacheruvu Mohana krishna

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 4;
Issue: 8;
Start page: 168;
Date: 2013;
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Keywords: Omeprazole | Fast dissolving tablets | calcium silicate | cross linked alginic acid.

ABSTRACT
Omeprazole is a proton pump inhibitor used in the treatment of dyspepsia, peptic ulcer disease (PUD), Gastroesophageal reflux disease (GERD), laryngopharyngeal reflux disease (LPR) and Zollinger-Ellison syndrome. The present study deals with the formulation of omeprazole fast dissolving tablets utilising cross linked alginic acid and calcium silicate as super disintegrates and a total of 8 formulation batches were prepared. All the pre compression and post compression parameters are studied and the results comply with in the limits. In vitro dissolution studies explained that the optimised F7 formulation with super disintegrants Cross linked alginic acid at low ratio and Calcium silicate at high ratio showed a cumulative release of 99.6 % of drug at the end of 12 minutes and also exhibited first order kinetics with Higuchi mechanism of drug release.
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