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Formulation and in Vivo Evaluation for Anti-Aging Effects of an Emulsion Containing Basil Extract Using non- Invasive Biophysical Techniques

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Author(s): A. Rasul | N. Akhtar

Journal: DARU : Journal of Pharmaceutical Sciences
ISSN 1560-8115

Volume: 19;
Issue: 5;
Start page: 344;
Date: 2011;
Original page

Keywords: Ocimum Basilicum | Surface Evaluation of Living Skin (SELS) | Transepidermal Water Loss (TEWL) | W/O Emulsion

ABSTRACT
Background and the purpose of study: Skin aging is a complex process induced by constant exposure to ultraviolet (UV) irradiation and damages human skin. UV generates reactive oxygen species leading to collagen deficiency and eventually skin wrinkling. Basil contains a number of phenolics and favonoids which possess antioxidant properties. The aim of this study was to formulate and investigate the antiaging potential of a cream containing Basil extract. Methods: A single blinded study was conducted using non-invasive methods. Formulation containing 3% of the concentrated extract of Basil was developed by entrapping in the inner aqueous phase of w/o emulsion and base contained no extract. Both creams were stored at different storage conditions of 8°C, 25°C, 40°C and 40°C+ 75% relative humidity to predict their stabilities. The formulation and base were evaluated for their effects on various skin parameters i.e., moisture and trans epidermal water loss (TEWL), volume, energy and surface evaluation of the living skin (SELS). Results: Significant effects (p≤0.05) were observed for both creams in the case of TEWL. The base showed insignificant (p≤0.05) while formulation showed significant effects on skin moisture. Volume, SELS SEr (skin roughness), SEsc (skin scaliness), SEsm (skin smoothness), SEw (skin wrinkles) parameter showed significant decline while texture parameter of ‘Energy' showed significant increase. Conclusion: The results statistically indicated that the active formulation containg extract of Basil exert antiaging effects when applied topically.
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