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Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp. BL321

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Author(s): Yongxiang Song | Jiajian Wang | Hongbo Huang | Lin Ma | Jun Wang | Yucheng Gu | Lan Liu | Yongcheng Lin

Journal: Marine Drugs
ISSN 1660-3397

Volume: 10;
Issue: 2;
Start page: 340;
Date: 2012;
Original page

Keywords: marine fungus | Xylaria sp. | mangrove | sesquiterpenes | α-glucosidase

ABSTRACT
Three new eremophilane sesquiterpenes (1–3) were isolated from the mangrove endophytic fungus Xylaria sp. BL321 together with 07H239-A (4), a known analogue of the new compounds. The structures of these compounds were elucidated by analysis of their MS, 1D and 2D NMR spectroscopic data. Compound 4 showed activation activity on α-glucosidase at 0.15 μM (146%), and then, 4 gradually produced inhibitory activity on α-glucosidase with increasing concentration, and the IC50 value is 6.54 μM.

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