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Frequency-dependent electrophysiological properties of concealed slow pathway of isolated rabbit atrioventricular node preparation after fast pathway ablation in a functional model

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Author(s): vahid khori | samaneh Naeimipour | Ali-Mohammad alizadeh | mona pourabouk | fakhri Badaghabadi | maryah Rajaei | sepideh Shariatnezhad | hamidreza Moheimani | saeed saleki | mohammadali Zeyghami | mohsen Nayebpour

Journal: Physiology and Pharmacology
ISSN 1735-0581

Volume: 16;
Issue: 1;
Start page: 21;
Date: 2012;
Original page

Keywords: Mathematical analysis | concealed slow pathway | fast pathway | ablation atrioventricular node

ABSTRACT
Introduction: Intranodal pathways of atrioventricular (AV) node play a vital role in the delay of conduction time in response to various atrial inputs. The present study was aimed to determine the frequency-dependent electrophysiological properties of concealed slow pathway according to a functional model of isolated rabbit atrioventricular node preparation after fast pathway ablation. Methods: Experiments were carried out in rabbit isolated heart AV-nodal preparations (N=8) by superfused/perfused mode. Extracellular recording was carried out from transitional cells of posterior and anterior extension of AV-node and upper part of atrium and its bundle. Unipolar silver electrode (100 μm) and direct voltage (100-110 V) was applied to create AV-nodal fast pathway ablation. Results: Minimum conduction time (AHmin) was significantly increased after fast pathway ablation (p
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