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Frequency of chromosomal aberrations in the evaluation of genotoxic potential of dicyclohexylamine (fumagillin) in vivo

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Author(s): Stanimirović Z. | Stevanović Jevrosima | Kulić M. | Stojić V.

Journal: Acta Veterinaria
ISSN 0567-8315

Volume: 56;
Issue: 4;
Start page: 353;
Date: 2006;
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Keywords: dicyclohexylamine (fumagillin) | honey bee | nosemadisease | genotoxicity | chromosome aberrations (CA) | Robertsonian chromosome Rb (4.19).

ABSTRACT
Dicyclohexylamine (fumagillin), as an antibiotic produced by fermentation of Aspergillus fumigatus, is used in human medicine for the treatment of intestinal microsporidiosis in patients with HIV infection, intestinal amebiasis and microsporidial keratoconjunctivitis. In veterinary medicine fumagillin is effective in suppressing microsporidiosis of bees and fish. In this study, the genotoxicity of fumagillin was evaluated in mouse bone marrow cells using chromosome aberrations (CA) assay. Dicyclohexylamine was administered to mice by gavage in a dose of 25, 50, 75 mg/kg b.w., with water-sugar syrup as the negative control and cyclophosphamide as the positive control (40 mg/kg b.w) Significantly increased frequency (p
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