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Frequency of Cytotoxin Associated Gene A(+) Helicobacter pylori in Peptic Ulcer Disease: Difference Between Gastric and Duodenal Ulcer Disease

Author(s): Y. Rasmi | M. Sadreddini | M. Jamali | T. Peirouvi | F. Khosravifar

Journal: Journal of Medical Sciences
ISSN 1682-4474

Volume: 9;
Issue: 3;
Start page: 146;
Date: 2009;
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Keywords: Peptic ulcer disease | H. pylori | cagA | duodenal | gastric

In this study, we evaluated the frequency of cytotoxin associated gene A (cagA) positive strains of Helicobacter pylori in patients with PUD-either Gastric Ulcer (GU) or Duodenal Ulcer (DU) in Iran. Seventy two patients (46 males and 26 females), who underwent endoscopy and diagnosed with PUD were considered for inclusion into present study. The presence of plasma IgG antibodies to H. pylori and cagA were determined by ELISA. Thirty nine patients diagnosed with DU were available for analysis of which 32 of them were positive for H. pylori antibodies (32/39: 82%). Twenty cases from infected DU samples were positive for cagA antibodies (20/32: 62.5%). Thirty three patients diagnosed with GU were available for analysis of which 19 were positive for H. pylori antibodies (19/33: 57.7%). Twelve cases from infected GU samples were positive for cagA antibodies (12/19: 63.2%). These results showed that duodenal ulcer has strong association with H. pylori infection than gastric ulcer (82 vs. 57.7%), but in the case of cagA positive strains of H. pylori, we found same association (62.5 vs. 63.2%, respectively). H. pylori and cagA (+) H. pylori prevalence in the GU and DU groups was found to be independent of age, sex and BMI (p>0.05).
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