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Frequency of extended spectrum beta-lactamase and resistance to antibiotics in Escherichia coli strains isolated from urinary cultures

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Author(s): Özcan Deveci | Erkan Yula | Alicem Tekin

Journal: Journal of Clinical and Experimental Investigations
ISSN 1309-8578

Volume: 1;
Issue: 3;
Start page: 182;
Date: 2010;
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Keywords: Extended spectrum beta-lactamase | Escherichia coli | antimicrobials | resistance

ABSTRACT
Objectives: Extended spectrum beta-lactamases (ESBL), are enzymes which can hydrolise cephalosporins and monobactams and usually responsible for resistance to beta-lactam antibiotics in Gram negative bacilli. The presence of ESBL in Escherichia coli strains isolated from urine samples in a State Hospital, was investigated and the sensitivity of these strains to some antibiotics was examined.Materials and methods: E. coli strains isolated from urinary cultures were identified by conventional methods. Antimicrobial susceptibility tests have been studied by using “Kirby-Bauer disk diffusion method”. Extended Spectrum β-Lactamase producing E. coli strains have been detected by using “double disk synergy test”.Results: In this study, the prevalence of ESBL producing isolates among E. coli was found to be 13%. The antimicrobial resistance rates of ESBL positive strains to many antibiotics which were not substrate for these enzymes were found higher than those of ESBL negative strains (p
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