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Functional Neuroimaging Study of Brain Activation due to Craving in Heroin Intravenous Users

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Author(s): Hamed Ekhtiari | Arian Behzadi | Habib Ganjahi | Azarakhsh Mokri | Hanieh Edalati | Morteza Bakhtiari | Naghmeh Rabiee | Mohammad Ali Oghabian

Journal: Iranian Journal of Psychiatry and Clinical Psychology
ISSN 1735-4315

Volume: 14;
Issue: 3;
Start page: 269;
Date: 2008;
Original page

Keywords: drug craving; intravenous heroin dependents | fMRI

ABSTRACT
Objectives: Regarding the importance of craving in the persistence of addiction, this study has been carried out with the aim of determining the differences between the two distinguishable groups of heroin addicts: responders and non-responders to craving cues. Method: In a case-control study, 26 male intravenous heroin addicts were selected from among non-treatment seeker abusing addicts in Tehran, and entered the study after a semi-structured interview and based on DSM-IV criteria. A demographic questionnaire and Addiction Severity Index were administered to all subjects before imaging. Each of the subjects underwent functional imaging with visual cue-induced craving, using functional magnetic resonance imaging (fMRI). Subjective reports of craving were evaluated after the imaging, using Visual Analog Scale (VAS). Also, 15 normal individuals with no history of drug abuse underwent fMRI as the control group. Blood-oxygen-level-dependent (BOLD) signal obtained during fMRI was analyzed using FSL. Results: There was a significant difference in brain activation between responder and non-responder groups (p

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