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The Functions of the Amyloid Precursor Protein Gene and Its Derivative Peptides: III Pharmacological Studies

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Author(s): Peter K. Panegyres | Emily R. Atkins

Journal: Neuroscience & Medicine
ISSN 2158-2912

Volume: 02;
Issue: 04;
Start page: 397;
Date: 2011;
Original page

Keywords: Amyloid Precursor Protein | APP | Genes | Dementia | Alzheimer’s Disease

ABSTRACT
Pharmacological studies reveal APP and Aβ have interactions with glutamate and calcium, cytokines, copper/zinc chelators, secretases and presenilins, nicotinic receptors, acetycholinesterase, neurotrophins, non-steroidal anti-inflame-matory drugs, monoclonal antibodies to Aβ, protease inhibitors, oestrogen, homocysteine, immediate early genes such as c-fos or c-jun and cholesterol. These functional and pharmacological observations highlight the need for greater understanding of APP and Aβ in brain function and have implications for clinical trials.

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