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GAS POWERED MUCOADHESIVE SYSTEM TO INCREASE GASTRIC RETENTION

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Author(s): Zikriya Abrar | Quazi Aamer | Jathar Rajashree | Supute Trupti

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 3;
Issue: 8;
Start page: 75;
Date: 2012;
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Keywords: Gas Powered System | Flotation | Gastric Residence Time | mucus | absorption.

ABSTRACT
A lot of scientific and technological advancements have been made in the drug delivery research in the recent years. Physiological problems like short Gastric Residence Time (GRT) and the unpredictable Gastric Emptying Time (GET) were overcome with the use of gas powered mucoadhesive dosage forms which provide opportunity for both local and systemic drug action. Several approaches are currently being used in the prolongation of GRT, which includes the Gas Powered Drug Delivery Systems (GPDDS), also known as Floating Drug Delivery System (FDDS). Floating and bioadhesive drug delivery systems have advantages such as efficient absorption and enhanced bioavailability of drugs owing to a high surface-to-volume ratio, a much more intimate contact with the mucus layer, and specific targeting of drugs to the absorption site. The purpose of this overview is to compile the recent advancements with special emphasis on the mechanism of floatation. In this overview we have discussed the approaches to gastroretentive drug delivery system mechanism of gas powered system, mechanism of mucoadhesion, and evaluation of bioadhesive gas powered system.
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