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Gastrointestinal mucoadhesive drug delivery system: A review

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Author(s): Permender Rathee1, Manish Jain1, Arun Garg1, Arun Nanda2, Ashima Hooda1*

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 5;
Start page: 1448;
Date: 2011;
Original page

Keywords: Intestinal transit time | Mucoadhesive Drug Delivery System | GI Patches

ABSTRACT
Mucoadhesion is a topic of current interest in the design of drug delivery systems. The Gastrointestinal Mucoadhesive drug delivery system prolong the residence time of the dosage form at the site of absorption and facilitate an intimate contact of the dosage form with the underline absorption surface and thus contribute to improved and / or better therapeutic performance of the drug. The process of mucoadhesion involving a polymeric drug delivery platform is a complex one that includes wetting, adsorption and interpenetration of polymer chains amongst various other processes. There are various factor influences the Gastro-Intestinal retention and mucoadhesion. This paper describes some effort to increase the residence time of drug dosage forms in GI tract, by gastroretentive units and bioadhesive gastrointestinal patches. Several gastrointestinal patch systems provide bioadhesion, drug protection and unidirectional release, This combination of function could improve the overall oral bioavailability.
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