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Gastroprotective effects of novel antidotal combination in rats acutely poisoned by T-2 toxin

Author(s): Jaćević Vesna | Resanović Radmila | Bočarov-Stančić Aleksandra | Đorđević Snežana | Dragojević-Simić Viktorija | Vukajlović Ana | Bokonjić D.

Journal: Acta Veterinaria
ISSN 0567-8315

Volume: 60;
Issue: 5-6;
Start page: 461;
Date: 2010;
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Keywords: gut | methylprednisolone | N-acetylcysteine | nimesulide | pathohistology | T-2 toxin

The purpose of this experiment was to evaluate the antidotal potencies of methylprednisolone (soluble form, Lemod-solu®), nimesulide, N-acetylcysteine (Fluimucil®) and their combinations in rats treated with 1.0 LD50 (0.23 mg/kg) of trichothecene mycotoxin, T-2 toxin. Their antidotal efficacy was investigated by monitoring their effects on general condition, 24-hour-survival, body weight gain, food and water consumption and pathohistological changes in the gut of Wistar rats acutely treated with a single injection of T-2 toxin during a 4-week period. The highest protective index was obtained with methylprednisolone (2.43). Initial loss of body weight (after first 7 days) was found only in T-2 toxin group. During the whole experiment, in poisoned rats protected by methylprednisolone or methylprednisolone and nimesulide, a significant increase (p
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