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Gene polymorphisms of renin-angiotensin-aldosterone system components and the progression of chronic kidney diseases

Author(s): Agata Kujawa-Szewieczek | Magdalena Kocierz | Grzegorz Piecha | Aureliusz Kolonko | Jerzy Chudek | Andrzej Więcek

Journal: Postępy Higieny i Medycyny Doświadczalnej
ISSN 0032-5449

Volume: 64;
Issue: 840537;
Start page: 423;
Date: 2010;
Original page

Keywords: układ renina-angiotensyna-aldosteron | polimorfizm | przewlekła choroba nerek | przeszczep nerki | przewlekłe odrzucanie | włóknienie śródmiąższu z zanikiem cewek | nadciśnienie tętnicze | nadkrwistość

The renin-angiotensin-aldosterone system (RAAS) plays an important role in the pathogenesis of hypertension as well as cardiovascular diseases and chronic kidney diseases. Among the most frequently studied RAAS gene polymorphisms are the angiotensin-converting enzyme insertion/deletion (I/D), angiotensinogen M235T and angiotensin II receptor type 1 A1166C polymorphisms.A significant correlation was found between the I/D polymorphism and cardiovascular morbidity and mortality rates. However, there was no significant correlation between I/D, M235T, A1166C polymorphism and arterial hypertension. The role of I/D polymorphism in the development and progression of chronic kidney disease is also non-conclusive. However, DD genotype has been identified as relevant for loss of renal function both in patients with IgA nephropathy and in patients of Asian origin with diabetic nephropathy.The relationship between RAAS gene polymorphism and transplanted kidney function has not been confirmed in large prospective and retrospective studies. Conclusion: there is no clear opinion concerning the influence of RAAS genotypes on the prevalence of post-transplant hypertension or erythrocytosis.Although a role of RAAS gene polymorphism in kidney function deterioration could not be ruled out, it is more likely that a variety of genetic and environmental factors influence the progression of chronic kidney diseases.
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