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Genetic Aspects of Premature Ovarian Failure

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Author(s): Wieacker P

Journal: Journal für Reproduktionsmedizin und Endokrinologie
ISSN 1810-2107

Volume: 6;
Issue: 1;
Start page: 17;
Date: 2009;
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Keywords: Chromosomenaberration | Genmutation | Humangenetik | POF | chromosome aberration | gene mutation | premature ovarian failure

ABSTRACT
Premature ovarian failure (POF) is characterized by the combination of amenorrhea before age 40 years and hypergonadotropic hypogonadism. The prevalence is approximately 1 %. Genetic causes of POF include chromosome aberrations and monogenic defects. Furthermore, polygenic-multifactorial inheritance can be assumed in a subset of cases.
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