Academic Journals Database
Disseminating quality controlled scientific knowledge

Genetics And Tooth Anomalies - An Update

Author(s): Aswathy Raj R | Deepa.M.S | Ahmed Hasan Farooqi T | Aswathy Brahmanandan

Journal: Oral & Maxillofacial Pathology Journal
ISSN 0976-1225

Volume: 4;
Issue: 1;
Start page: 334;
Date: 2013;
VIEW PDF   PDF DOWNLOAD PDF   Download PDF Original page

Keywords: Amelogenesis imperfecta | Genetics | Mutation | Odontogenesis

Tooth development like the development of all epithelial appendages is regulated by inductive tissue interactions between epithelium and mesenchyme. Numerous genes interact, either act in conjunction or antagonize each other in odontogenesis. A number of different mesenchymal molecules and their receptors act as mediators in epithelial mesenchymal interactions. Several genes linked with early tooth positioning and developments belong to signaling pathways and have morphogenesis regulatory functions in morphogenesis of other organs. Their mutations often show pleiotropic effects beyond dental morphogenesis. In contrast, certain genes involved in enamel and dentin structures are highly specific for tooth. Mutations in these genes have been identified as causes of Amelogenesis Imperfecta (AI), Dentinogenesis Imperfecta (DI), Dentin Dysplasia (DD) and anomalies in tooth number. This article focuses on genetic basis of inherited non-syndromic teeth disorders.
Why do you need a reservation system?      Save time & money - Smart Internet Solutions