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Genome-Wide Transcriptional Profiling of the Response of Staphylococcus aureus to Cryptotanshinone

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Author(s): Haihua Feng | Hua Xiang | Jiyu Zhang | Guowen Liu | Na Guo | Xuelin Wang | Xiuping Wu | Xuming Deng | Lu Yu

Journal: Journal of Biomedicine and Biotechnology
ISSN 1110-7243

Volume: 2009;
Date: 2009;
Original page

ABSTRACT
Staphylococcus aureus (S. aureus) strains with multiple antibiotic resistances are increasingly widespread, and new agents are required for the treatment of S. aureus. Cryptotanshinone (CT), a major tanshinone of medicinal plant Salvia miltiorrhiza Bunge, demonstrated effective in vitro antibacterial activity against all 21 S. aureus strains tested in this experiment. Affymetrix GeneChips were utilized to determine the global transcriptional response of S. aureus ATCC 25923 to treatment with subinhibitory concentrations of CT. Transcriptome profiling indicated that the antibacterial action of CT may be associated with its action as active oxygen radical generator; S. aureus undergoes an oxygen-limiting state upon exposure to CT.

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Tangokurs Rapperswil-Jona

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