Academic Journals Database
Disseminating quality controlled scientific knowledge

A genome scan for quantitative trait loci affecting the Salmonella carrier-state in the chicken

ADD TO MY LIST
 
Author(s): Tilquin Pierre | Barrow Paul | Marly José | Pitel Frédérique | Plisson-Petit Florence | Velge Philippe | Vignal Alain | Baret Philippe | Bumstead Nat | Beaumont Catherine

Journal: Genetics Selection Evolution
ISSN 0999-193X

Volume: 37;
Issue: 6;
Start page: 539;
Date: 2005;
Original page

Keywords: fowl | genetic resistance | Salmonella | carrier-state | SLC11A1

ABSTRACT
Abstract Selection for increased resistance to Salmonella colonisation and excretion could reduce the risk of foodborne Salmonella infection. In order to identify potential loci affecting resistance, differences in resistance were identified between the N and 61 inbred lines and two QTL research performed. In an F2 cross, the animals were inoculated at one week of age with Salmonella enteritidis and cloacal swabs were carried out 4 and 5 wk post inoculation (thereafter called CSW4F2 and CSW4F2) and caecal contamination (CAECF2) was assessed 1 week later. The animals from the (N × 61) × N backcross were inoculated at six weeks of age with Salmonella typhimurium and cloacal swabs were studied from wk 1 to 4 (thereafter called CSW1BC to CSW4BC). A total of 33 F2 and 46 backcross progeny were selectively genotyped for 103 and 135 microsatellite markers respectively. The analysis used least-squares-based and non-parametric interval mapping. Two genome-wise significant QTL were observed on Chromosome 1 for CSW2BC and on Chromosome 2 for CSW4F2, and four suggestive QTL for CSW5F2 on Chromosome 2, for CSW5F2 and CSW2BC on chromosome 5 and for CAECF2 on chromosome 16. These results suggest new regions of interest and the putative role of SAL1.

Tango Jona
Tangokurs Rapperswil-Jona

     Save time & money - Smart Internet Solutions