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Genotoxicity evaluation by means of the lethal dominant assay, a technical article

Author(s): Tamara Hernández Salazar | Daniel Francisco Arencibia Arrebola | Luis Alfredo Rosario Fernández

Journal: RETEL : Revista de Toxicología en Línea
ISSN 1668-091X

Volume: 27;
Start page: 9;
Date: 2010;
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Keywords: Genotoxicity | lethal dominant assay | in vivo assays | experimental procedure

The lethal dominant in vivo genotoxicity assay it measures the induced genetic changes in a dominant way that kill to the zygote. The objective of this work is to define the protocol of this test in mice, standardized under our experimental conditions, which would help to provide to the toxicologists of a departure material for the realization these in vivo assay in their laboratories. We considered the experimental procedure, the variables to analyze and the statistical analysis of the results.
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