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GENOTYPES OF THE HELICOBACTER PYLORI ISOLATES AND THE IL-1 GENES IN KAZAN CITIZENS (KAZAN, RUSSIA) WITH GASTRIC AND DUODENAL ULCER

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Author(s): Olga A. Chernova | Elmira R. Nasybullina | Vladislav M. Chernov | Oleg V. Gorshkov | Gulnara F. Shaimordanova | Rustem A. Abdulhakov | Maxim V. Trushin

Journal: Electronic Journal of Biomedicine
ISSN 1697-090X

Volume: 2006;
Issue: 1;
Start page: 13;
Date: 2006;
Original page

Keywords: Helicobacter pylori | virulence genes | IL-1 genes | genotyping | ulcer disease | persistence | Ureaplasma urealyticum

ABSTRACT
The prevalence of the virulence genes (iceA, cagA, babA2, vacA) in the Helicobacter pylori strains isolated from patients with clinic and histologically proved diagnosis of gastric and duodenal ulcer as well as the distinction of the IL-1 genes in the helicobacter carriers were studied. VacA s1/m2 iceA1 cagA+ and vacA s1/m2 iceA1 cagA+ babA2 genotypes of H. pylori were shown to be the prevalent in the clinic isolates. Four patients were found to be infected with Ureaplasma urealyticum. The combination of the IL-1B-511*?/IL-1B+3954*C/IL-1RN*2 alleles was shown to be the prevalent among the patients with gastric and duodenal ulcer. The correlation between the H. pylori genotypes, the IL-1 genes and the ulcer particularity was not found.
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