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Gliptins: A new class of oral antidiabetic agents

Author(s): Seshadri K | Kirubha MHB

Journal: Indian Journal of Pharmaceutical Sciences
ISSN 0250-474X

Volume: 71;
Issue: 6;
Start page: 608;
Date: 2009;
Original page

Keywords: Dipeptidyl peptidase-4 (DPP-4) inhibitors | glucagon like peptide-1 (GLP-1) | sitagliptin | Type 2 Diabetes Mellitus

India has the largest population of patients with type 2 diabetes mellitus. The conventional agents used to treat type 2 diabetes frequently exhibit reduced efficacy over time leading to inadequate glycaemic control and are also associated with adverse effects. Hence, there is a need for alternative therapies that can overcome the limitations associated with conventional antidiabetic agents. This review focuses on Gliptins, which have become a research area of intense focus and present an alternative therapeutic strategy for patients with type 2 diabetes. Gliptins show significant improvements in glycaemic control and are well tolerated, particularly with regard to weight change and hypoglycemia. Hence, gliptins are considered as useful agents for the treatment of type 2 diabetes mellitus.
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