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Glutathione Peroxidase-like Activities of Oxygen-Containing Diselenides

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Author(s): Thomas Wirth

Journal: Molecules
ISSN 1420-3049

Volume: 3;
Issue: 7;
Start page: 164;
Date: 1998;
Original page

Keywords: Antioxidants | diselenides | glutatione oxidase | glutathione peroxidase | oxidative stress

ABSTRACT
Various diselenides 1 – 8 have been examined with respect to their glutathione peroxidase-like activities (GPx-activities) as an index of their antioxidant properties. The glutathione oxidase activities of these compounds have also been reviewed reflecting the pro-oxidant properties (GOx-activities) and could be used as an index of cell toxicity. Based on a qualitative structure-activity relationship some trends are suggested.
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